GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer

Published: Jun 25, 2019
Abstract
Whole exome sequencing (WES) recently identified frequent mutations in the genes of GPCR-mediated PI3K pathway (LPAR4, PIK3CA, and PTEN) in a Chinese population with papillary thyroid cancers (PTCs). The study found LPAR4 mutations as novel gene mutations in adult population with differentiated thyroid cancer (DTC). Here, we determine the prevalence of somatic mutations in this pathway (LPAR4 (exon 1), PIK3CA (exons 9 and 20) and PTEN (exons 5,...
Paper Details
Title
GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer
Published Date
Jun 25, 2019
Journal
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