Lamin A/C deficiency in CD4 ⁺ T‐cells enhances regulatory T‐cells and prevents inflammatory bowel disease

The mechanisms by which lamin A/C in CD4 + T‐cells control intestinal homeostasis and can cause inflammatory bowel disease (IBD) are unknown. Here, we explore lamin A/C in a mouse model of IBD. Adoptive transfer to Rag1 −/− mice of Lmna −/− CD4 + T‐cells, which have enhanced regulatory T‐cells (Treg) differentiation and function, induced less severe IBD than wild‐type T‐cells. Lamin A/C deficiency in CD4 + T‐cells enhanced transcription of the...