Antisense oligonucleotides extend survival of prion-infected mice
Abstract
Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals caused by conversion of cellular prion protein (PrPC) into a self-propagating neurotoxic conformer (prions; PrPSc). Strong genetic proofs of concept support lowering PrP expression as a therapeutic strategy. Antisense oligonucleotides (ASOs) can provide a practical route to lowering 1 target mRNA in the brain, but their development for prion disease has...
Paper Details
Title
Antisense oligonucleotides extend survival of prion-infected mice
Published Date
Aug 22, 2019
Journal
Volume
4
Issue
16
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