MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells
Abstract
Natural killer (NK) cells are cytotoxic type 1 innate lymphoid cells (ILCs) that defend against viruses and mediate anti-tumor responses, yet mechanisms controlling their development and function remain incompletely understood. We hypothesized that the abundantly expressed microRNA-142 (miR-142) is a critical regulator of type 1 ILC biology. Interleukin-15 (IL-15) signaling induced miR-142 expression, whereas global and ILC-specific...
Paper Details
Title
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells
Published Date
Sep 1, 2019
Journal
Volume
51
Issue
3
Pages
479 - 490.e6
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