A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice

Volume: 317, Issue: 5, Pages: E820 - E830
Published: Nov 1, 2019
Abstract
Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term high-fat diet (HFD) feeding results in so-called ‘whitening’ of BAT characterized by increased lipid deposition, mitochondrial dysfunction, and reduced fat oxidation. The aim of the current study was to unravel the rate and related mechanisms by which HFD induces BAT whitening and insulin resistance. Wild-type...
Paper Details
Title
A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice
Published Date
Nov 1, 2019
Volume
317
Issue
5
Pages
E820 - E830
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