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Epicardial adipocyte size does not correlate with body mass index

Published on 2019in Cardiovascular Pathology1.76
· DOI :10.1016/j.carpath.2019.07.003
H. Aitken-Buck (University of Otago), Aram A Babakr (University of Otago)+ 3 AuthorsRegis R. Lamberts14
Estimated H-index: 14
(University of Otago)
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Abstract
Abstract Background Epicardial adipose tissue (EAT) deposition has a strong association with aspects of metabolic dysfunction, including obesity. The size of the EAT adipocytes in relation to obesity, however, has rarely been researched. Therefore, to contextualise EAT within the broader framework of pathophysiological adipocyte size changes in obesity, we aimed to determine whether EAT adipocyte size is associated with body mass index (BMI). Methods During routine post-mortem examination, adipose tissue biopsies were obtained from four depots of 43 cases, including EAT, as well as pericardial (PAT), appendix mesenteric (AAT), and clavicular subcutaneous (SAT) adipose tissues. Tissues were fixed, sectioned, and stained using haematoxylin and eosin. The size (measured as area) of each adipocyte imaged from the depots was analysed in relation to BMI. Results Mean size of EAT adipocytes was significantly smaller than that from SAT and AAT depots, while not differing from PAT adipocytes. BMI positively correlated with the size of adipocytes isolated from SAT (r=0.5893, P Conclusions EAT adipocyte size is not associated with increased BMI despite significant associations within adipocytes from other adipose depots.
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Published on Mar 7, 2018in The Journal of Experimental Biology3.02
Panna Tandon2
Estimated H-index: 2
(BHF: British Heart Foundation),
Rebecca Wafer1
Estimated H-index: 1
(BHF: British Heart Foundation),
James E. N. Minchin6
Estimated H-index: 6
(BHF: British Heart Foundation)
ABSTRACT Adipose morphology is defined as the number and size distribution of adipocytes (fat cells) within adipose tissue. Adipose tissue with fewer but larger adipocytes is said to have a ‘hypertrophic’ morphology, whereas adipose with many adipocytes of a smaller size is said to have a ‘hyperplastic’ morphology. Hypertrophic adipose morphology is positively associated with insulin resistance, diabetes and cardiovascular disease. By contrast, hyperplastic morphology is associated with improved...
Published on Nov 1, 2014in International Journal of Obesity4.51
Sini Heinonen8
Estimated H-index: 8
,
Lilli Saarinen8
Estimated H-index: 8
+ 13 AuthorsEeva Moilanen48
Estimated H-index: 48
BACKGROUND: Adipocyte size and number have been suggested to predict the development of metabolic complications inobesity. However, the genetic and environmental determinants behind this phenomenon remain unclear.METHODS: We studied this question in rare-weight discordant (intra-pair difference (Δ) body mass index (BMI) 3–10kgm
Published on Mar 1, 2014in Obesity3.97
Tracey McLaughlin40
Estimated H-index: 40
(Stanford University),
C. Lamendola17
Estimated H-index: 17
(Stanford University)
+ 4 AuthorsSamuel W. Cushman55
Estimated H-index: 55
(NIH: National Institutes of Health)
Objective Metabolic heterogeneity among obese individuals may be attributable to differences in adipose cell size. We sought to clarify this by quantifying adipose cell size distribution, body fat, and insulin-mediated glucose uptake in overweight to moderately-obese individuals. Methods A total of 148 healthy nondiabetic subjects with BMI 25-38 kg/m2 underwent subcutaneous adipose tissue biopsies and quantification of insulin-mediated glucose uptake with steady-state plasma glucose (SSPG) conce...
Published on Feb 1, 2014in Metabolic Syndrome and Related Disorders1.60
W RabkinSimon1
Estimated H-index: 1
Abstract Epicardial fat (epicardial adipose tissue, EAT) has been implicated in the pathogenesis of coronary artery disease (CAD). The objective of this study was to examine the relationship between EAT and generalized obesity, central or visceral adipose tissue (VAT), and the components of the metabolic syndrome—systolic blood pressure (SBP), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG)—that are linked to CAD. A systematic review of the lite...
Published on Jan 1, 2013in American Journal of Cardiology2.84
Sante D. Pierdomenico36
Estimated H-index: 36
,
Anna M. Pierdomenico8
Estimated H-index: 8
+ 1 AuthorsGianluca Iacobellis36
Estimated H-index: 36
(UM: University of Miami)
Epicardial adipose tissue (EAT) is an emerging cardiometabolic risk factor, and its thickness can be measured using echocardiography. The relation of EAT to the metabolic syndrome (MS) is still unclear. A meta-analysis of published reports was performed to provide comprehensive insight on the association of EAT thickness as assessed by echocardiography and the MS. A systematic search was conducted for reports on echocardiographic EAT thickness in patients with and without the MS. Nine studies we...
Published on May 1, 2012in Obesity3.97
Jian Yang2
Estimated H-index: 2
(USA: University of South Alabama),
Björn Eliasson45
Estimated H-index: 45
(Sahlgrenska University Hospital)
+ 2 AuthorsArthur Sherman45
Estimated H-index: 45
(NIH: National Institutes of Health)
Early studies reported that the size of adipose cells correlates with insulin resistance. However, a recent study comparing moderately obese, sensitive and resistant subjects, with comparable BMI (∼30), did not detect any significant difference in the size of the large cells, but rather a smaller proportion of large cells in the resistant subjects, suggesting impaired adipogenesis. We hypothesize that a decreased proportion, rather than the size, of large adipose cells is also associated with in...
Published on May 1, 2011in Diabetes7.20
Alain Veilleux14
Estimated H-index: 14
,
Maude Caron-Jobin3
Estimated H-index: 3
+ 2 AuthorsAndré Tchernof48
Estimated H-index: 48
OBJECTIVE We assessed whether subcutaneous and omental adipocyte hypertrophy are related to metabolic alterations independent of body composition and fat distribution in women. RESEARCH DESIGN AND METHODS Mean adipocyte diameter of paired subcutaneous and omental adipose tissue samples was obtained in lean to obese women. Linear regression models predicting adipocyte size in both adipose tissue depots were computed using body composition and fat distribution measures ( n = 150). In a given depot...
Published on Aug 1, 2010in Cytokine3.08
Sonia Eiras16
Estimated H-index: 16
,
Elvis Teijeira-Fernández14
Estimated H-index: 14
(University of Santiago de Compostela)
+ 4 AuthorsJosé Ramón González Juanatey1
Estimated H-index: 1
(University of Santiago de Compostela)
Abstract Adipocyte size has been associated to increase in inflammatory cytokines expression that can be related to the cardiovascular risk of obesity. Epicardial adipose tissue (EAT) was discovered to play a key role in cardiovascular diseases by producing several inflammatory adipokines. We sought to study whether EAT and subcutaneous adipose tissue (SAT) mean adipocyte sizes are related to the expression of adipokines in patients with cardiovascular diseases. We collected EAT, SAT and blood s...
Published on Nov 1, 2009in Obesity Surgery3.60
Alice Liu11
Estimated H-index: 11
(Stanford University),
Tracey McLaughlin40
Estimated H-index: 40
(Stanford University)
+ 8 AuthorsGerald M. Reaven113
Estimated H-index: 113
(Stanford University)
Background We recently identified differences in abdominal subcutaneous adipose tissue (SAT) from insulin-resistant (IR) as compared to obesity-matched insulin sensitive individuals, including accumulation of small adipose cells, decreased expression of cell differentiation markers, and increased inflammatory activity. This study was initiated to see if these changes in SAT of IR individuals were present in omental visceral adipose tissue (VAT); in this instance, individuals were chosen to be IR...
Published on Jan 1, 2008in The American Journal of Clinical Nutrition6.57
Yourka D. Tchoukalova9
Estimated H-index: 9
(Pennington Biomedical Research Center),
Christina Koutsari19
Estimated H-index: 19
(Mayo Clinic)
+ 3 AuthorsMichael Dennis Jensen68
Estimated H-index: 68
Background: Both body fat distribution and adipocyte size are associated with metabolic abnormalities. Objective: We defined the extent to which subcutaneous adipocyte size is related to regional fat mass and to the sizes of adipocytes in other subcutaneous depots independent of adiposity, age, and sex. Design: Data collected from 188 women and 133 men who were 18-50 y old and who had a body mass index (in kg/m 2 ) of 18 to 50 were analyzed. The mean size of isolated subcutaneous abdominal, femo...
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