Mitophagy protects against statin‐mediated skeletal muscle toxicity
Abstract
The deleterious effects of statins on skeletal muscle are well known, but the mechanism associated with these effects remains unresolved. Statins are associated with mitochondrial damage, which may contribute to muscle myopathy. Here we demonstrate that simvastatin induces mitophagy in skeletal muscle cells and hypothesized that attenuating this process by silencing the mitophagy adapter p62/sequestosome-1 (SQSTM1) might mitigate myotoxicity....
Paper Details
Title
Mitophagy protects against statin‐mediated skeletal muscle toxicity
Published Date
Aug 23, 2019
Journal
Volume
33
Issue
11
Pages
11857 - 11869
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