Study of the Inducible Cross-Linking Reaction to mRNA and the Effect on the Translation
Abstract
The 4-vinylpyrimidin-2-one nucleoside (T-vinyl) forms a cross-link with the RNA containing uracil at the complementary site at a high reaction rate. To obtain the stable T-vinyl derivative so that its reactivity is protected until it access to the target site, several derivatives were investigated, and the 2-thiopyridinyl- and 2-thiopyrimidinyl T-vinyl derivatives were determined to be good candidates. The 2-thiopyrimidinyl T-vinyl derivative...
Paper Details
Title
Study of the Inducible Cross-Linking Reaction to mRNA and the Effect on the Translation
Published Date
Aug 1, 2019
Volume
67
Issue
8
Pages
877 - 883
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