SKA3 up-regulation promotes lung adenocarcinoma growth and is a predictor of poor prognosis

Objective The objective of this research is to investigate the expression and function of SKA3 in lung adenocarcinoma. Methods The mRNA expression level of SKA3 in lung adenocarcinoma and its association with clinic-pathological factors were analyzed using data obtained from the TCGA database. Small interfering RNA (siRNA) for SKA3 (si-SKA3) was used to down-regulate SKA3 in A549 cells. pcDNA3.1- SKA3 was used to overexpress SKA3 in A549 cells....