Innate Immune Control of Adipose Tissue Homeostasis

Published on 2019in Trends in Immunology13.00
· DOI :10.1016/
Harry Kane (Trinity College, Dublin), Lydia Lynch23
Estimated H-index: 23
(Trinity College, Dublin)
Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis. Recently, the immune system has been implicated in the regulation of adipose tissue homeostasis and function. Here, we highlight new insights into the distinct phenotypes and functions of adipose resident leukocytes, including a growing body of work on their role in adipose tissue remodeling and thermogenesis. We discuss how the protective capacity of the adipose immune system can be diminished during obesity, where immune cells promote sterile inflammation leading to insulin resistance. Understanding the role of adipose immune cells across different physiological states and processes is important in understanding the full breadth of adipose immunity and the possibilities to harness immune cells in fat tissue for the treatment of chronic metabolic conditions, including obesity.
  • References (120)
  • Citations (0)
#1Hernandez Moura Silva (NYU: New York University)H-Index: 8
#2André Báfica (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
Last.Patricia Martin (NYU: New York University)H-Index: 2
view all 10 authors...
#1Edward T. Chouchani (Harvard University)H-Index: 21
#2Lawrence Kazak (McGill University)H-Index: 16
Last.Bruce M. Spiegelman (Harvard University)H-Index: 166
view all 3 authors...
#1Eun-Hui Lee (Gachon University)H-Index: 1
#2Michal Itan (TAU: Tel Aviv University)H-Index: 8
Last.Joo Young Roh (Gachon University)H-Index: 8
view all 10 authors...
#1Kyoung-Jin Chung (TUD: Dresden University of Technology)H-Index: 12
#2Marina Nati (TUD: Dresden University of Technology)H-Index: 3
Last.Antonios Chatzigeorgiou (TUD: Dresden University of Technology)H-Index: 15
view all 4 authors...
#1Camille Khairallah (SBU: Stony Brook University)H-Index: 2
#2Timothy Chu (SBU: Stony Brook University)H-Index: 1
Last.Brian S. Sheridan (SBU: Stony Brook University)H-Index: 5
view all 3 authors...
#1Nelson M. LaMarche (Harvard University)H-Index: 3
#2Ayano C. Kohlgruber (Brigham and Women's Hospital)H-Index: 7
Last.Michael B. Brenner (Harvard University)H-Index: 95
view all 3 authors...
#1Chaoran Li (Brigham and Women's Hospital)H-Index: 2
#2Joanna R. DiSpirito (Brigham and Women's Hospital)H-Index: 9
Last.Diane Mathis (Brigham and Women's Hospital)H-Index: 113
view all 7 authors...
Cited By0
View next paperAdipose tissue inflammation in obesity: a metabolic or immune response?