Urinary PGE-M Levels and Risk of Ovarian Cancer

Background: Regular aspirin use may lower ovarian cancer risk by blocking the cyclooxygenase enzymes, resulting in lower expression of prostaglandins, including prostaglandin E2 (PGE2). We evaluated whether higher prediagnosis PGE-M (a urinary biomarker of PGE2) was associated with increased ovarian cancer risk in three prospective cohorts. Methods: We conducted a case–control study nested in the Nurses' Health Study (NHS), NHSII, and Shanghai...