Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant
Abstract
Precise editing of genomic DNA can be achieved upon repair of CRISPR-induced DNA double-stranded breaks (DSBs) by homology-directed repair (HDR). However, the efficiency of this process is limited by DSB repair pathways competing with HDR, such as non-homologous end joining (NHEJ). Here we individually express in human cells 204 open reading frames involved in the DNA damage response (DDR) and determine their impact on CRISPR-mediated HDR. From...
Paper Details
Title
Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant
Published Date
Jul 30, 2019
Journal
Volume
10
Issue
1
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