Influence of pH and organic modifiers on the dissociation constants of selected drugs using reversed‐phase thin‐layer chromatography: Comparison with other techniques and computational tools

Knowledge of the acid–base dissociation constants of drugs is the key to understanding their biopharmaceutical characteristics. In the present work, the effect of pH and organic modifiers (acetonitrile and methanol) was investigated in the determination of dissociation constants (p K a ) of nine representative drugs (atenolol, betahistine, clarithromycin, deferiprone, diclofenac, ibuprofen, metoprolol, naproxen and propranolol) using...