Clinical Management And Genetic Architecture Of Severe Hypercholesterolemia In Finland

Background and Aims: Severe hypercholesterolemia is a significant risk factor for coronary artery disease (CAD). Despite its strong genetic predisposition, Finnish patients remain inadequately identified and only a part of their mutation load is known. To characterize the prevalence, clinical management and underlying genetic architecture we studied patients with severe hypercholesterolemia (LDL-cholesterol ≥ 5mmol/l) in the prospective...