Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response
Abstract
Cholangiopathies such as primary sclerosing cholangitis (PSC) are chronic liver diseases characterized by increased cholestasis, biliary inflammation and oxidative stress. The objective of this study was to elucidate the impact of cholestatic injury on oxidative stress-related factors. Using hepatic tissue and whole cell liver extracts (LE) isolated from 11-week old C57BL/6J (WT) and Mdr2KO mice, inflammation and oxidative stress was assessed....
Paper Details
Title
Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response
Published Date
Nov 1, 2019
Volume
143
Pages
101 - 114
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