Cooperative control of oxidative metabolism by PGC‐1α and PPARβ: implications for exercise‐induced mitochondrial remodelling in skeletal muscle

Mitochondria undergo robust morphological and functional changes in response to a number of environmental conditions. For instance, physical exercise, myogenesis and cold exposure are known to induce mitochondrial biogenesis in skeletal muscle. The transcriptional co-activator peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 alpha (PGC-1α) is an established regulator of skeletal muscle mitochondrial biogenesis, though recent...