Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
Abstract
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders. Indeed, PDE9A inhibitors are under evaluation in clinical trials as a treatment for Alzheimer’s disease and schizophrenia. However, little is known about the cGMP signaling cascades regulated by PDE9A. Canonical cGMP signaling in brain follows the activation of neuronal nitric...
Paper Details
Title
Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
Published Date
Aug 23, 2019
Journal
Volume
13
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