The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
Abstract
Lineage plasticity has emerged as an important mechanism of treatment resistance in prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss of luminal prostate markers, and in many cases induction of developmental programs, stem cell–like phenotypes, and neuroendocrine/neuronal features. Clinically, lineage plasticity may manifest as low PSA progression, resistance to androgen receptor (AR) pathway...
Paper Details
Title
The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
Published Date
Dec 1, 2019
Journal
Volume
25
Issue
23
Pages
6916 - 6924
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