Trolox prevents high glucose‐induced apoptosis in rat myocardial H9c2 cells by regulating GLUT‐4 and antioxidant defense mechanism

Redox imbalance due to hyperglycemia is a causative factor for an increased generation of reactive oxygen species (ROS) that leads to mitochondrial dysfunction and the release of cytochrome‐c. The aim of the present study is to elucidate the functional role of oxidative stress (OS) in the induction of apoptosis in H9c2 cells in the hyperglycemic state through glucose transporter‐4 (GLUT‐4) regulation and antioxidant status. H9c2 cells were...