The case for using Mapped Exonic Non-Duplicate (MEND) read counts in RNA-Seq experiments: examples from pediatric cancer datasets

Pages: 716829
Published: Jul 30, 2019
Abstract
Background The accuracy of gene expression as measured by RNA sequencing (RNA-Seq) is dependent on the amount of sequencing performed. However, some types of reads are not informative for determining this accuracy. Unmapped and non-exonic reads do not contribute to gene expression quantification. Duplicate reads can be the product of high gene expression or technical errors. Findings We surveyed bulk RNA-Seq datasets from 2179 tumors in 48...
Paper Details
Title
The case for using Mapped Exonic Non-Duplicate (MEND) read counts in RNA-Seq experiments: examples from pediatric cancer datasets
Published Date
Jul 30, 2019
Journal
Pages
716829
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