27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-Induced Inflammatory Signaling
Abstract
27-Hydroxycholesterol (27HC) is an abundant cholesterol metabolite and has detrimental effects on the cardiovascular system, whereas its impact on adiposity is not well known. In this study, we found that elevations in 27HC cause increased body weight gain in mice fed a high-fat/high-cholesterol diet in an estrogen receptor α–dependent manner. Regardless of diet type, body fat mass was increased by 27HC without changes in food intake or fat...
Paper Details
Title
27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-Induced Inflammatory Signaling
Published Date
Aug 6, 2019
Journal
Volume
160
Issue
10
Pages
2485 - 2494
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