Perinatal iron deficiency combined with a high salt diet in adulthood causes sex‐dependent vascular dysfunction in rats

Key points Perinatal iron deficiency causes changes in offspring mesenteric artery function in adulthood, particularly in males, which can be exacerbated by chronic intake of a high salt diet. Perinatal iron deficient male offspring exhibit enhanced conversion of big endothelin‐1 to active endothelin‐1, coinciding with decreased nitric oxide levels. Perinatal iron deficient male offspring have reduced nitric oxide‐mediated endothelial‐dependent...