The Saturated Fat Controversy: finding Calmness in Chaos

Published on May 1, 2019in Indian heart journal
· DOI :10.1016/j.ihj.2019.07.003
Mohit D. Gupta10
Estimated H-index: 10
M.P. Girish5
Estimated H-index: 5
Rakesh Yadav12
Estimated H-index: 12
(AIIMS: All India Institute of Medical Sciences)
  • References (11)
  • Citations (0)
#1Mahshid Dehghan (Population Health Research Institute)H-Index: 24
#2Andrew Mente (McMaster University)H-Index: 32
Last. R MapangaH-Index: 4
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Summary Background The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear. Methods The Prospective Urban Rural Epidemiology (PURE) study is a large, epidemiological cohort study of individuals aged 35–70 years (enrolled between Jan 1, 2003, and March 31, 2013) in 18 countries with a median fo...
224 CitationsSource
#1Bridget A. Hannon (UIUC: University of Illinois at Urbana–Champaign)H-Index: 3
#2Sharon V. Thompson (UIUC: University of Illinois at Urbana–Champaign)H-Index: 7
Last. Margarita Teran-Garcia (Illinois College)H-Index: 18
view all 4 authors...
Background: Obesity and dyslipidemia are frequently treated with dietary interventions before pharmacotherapy is given. Diets high in unsaturated fat have proven
12 CitationsSource
ABSTRACTHistorically, the so-called “lipid hypothesis” has focused on the detrimental role of saturated fats per se in enhancing the risks of cardiovascular disease. Recently, a body of new information and systematic analyses of available data have questioned simple interpretation of the relationship of dietary saturated fats and of individual saturated fatty acids to CVD risk. Thus, current assessments of risks due to dietary fat consumption that emphasize the confounding nature of the dietary ...
24 CitationsSource
#1Jaike Praagman (UU: Utrecht University)H-Index: 4
#2Joline W.J. Beulens (UU: Utrecht University)H-Index: 50
Last. Y. T. van der Schouw (UU: Utrecht University)H-Index: 88
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Background: The association between saturated fatty acid (SFA) intake and ischemic heart disease (IHD) risk is debated. Objective: We sought to investigate whether dietary SFAs were associated with IHD risk and whether associations depended on 1) the substituting macronutrient, 2) the carbon chain length of SFAs, and 3) the SFA food source. Design: Baseline (1993-1997) SFA intake was measured with a foodfrequency questionnaire among 35,597 participants from the European Prospective Investigation...
65 CitationsSource
#1Russell J. de SouzaH-Index: 34
#2Andrew Mente (McMaster University)H-Index: 32
Last. Sonia S. AnandH-Index: 76
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Objective To systematically review associations between intake of saturated fat and trans unsaturated fat and all cause mortality, cardiovascular disease (CVD) and associated mortality, coronary heart disease (CHD) and associated mortality, ischemic stroke, and type 2 diabetes. Design Systematic review and meta-analysis. Data sources Medline, Embase, Cochrane Central Registry of Controlled Trials, Evidence-Based Medicine Reviews, and CINAHL from inception to 1 May 2015, supplemented by bibliogra...
384 CitationsSource
#1Zoë Harcombe (University of the West of Scotland)H-Index: 7
#2Julien S. Baker (University of the West of Scotland)H-Index: 31
Last. Fergal M. Grace (University of the West of Scotland)H-Index: 18
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Objectives: National dietary guidelines were introduced in 1977 and 1983, by the US and UK governments, respectively, with the ambition of reducing coronary heart disease (CHD) by reducing fat intake. To date, no analysis of the evidence base for these recommendations has been undertaken. The present study examines the evidence from randomised controlled trials (RCTs) available to the US and UK regulatory committees at their respective points of implementation. Methods: A systematic review and m...
84 CitationsSource
Primary Funding Source: British Heart Foundation, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, and Gates Cambridge.
650 CitationsSource
Abstract. Willett WC (Harvard School of Public Health, Boston, MA, USA). Dietary fats and coronary heart disease (Review). J Intern Med 2012; 272: 13–24. The relation of dietary fat to risk of coronary heart disease (CHD) has been studied extensively using many approaches, including controlled feeding studies with surrogate end-points such as plasma lipids, limited randomized trials and large cohort studies. All lines of evidence indicate that specific dietary fatty acids play important roles in...
163 CitationsSource
#1Patty W. Siri-Tarino (Children's Hospital Oakland Research Institute)H-Index: 8
#2Qi Sun (Children's Hospital Oakland Research Institute)H-Index: 62
Last. Ronald M. Krauss (Children's Hospital Oakland Research Institute)H-Index: 116
view all 4 authors...
Background: A reduction in dietary saturated fat has generally been thought to improve cardiovascular health. Objective: The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies. Design: Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualifie...
766 CitationsSource
#1K.G. Nevin (UoK: University of Kerala)H-Index: 1
#2T. Rajamohan (UoK: University of Kerala)H-Index: 1
Objectives: The present study was conducted to investigate the effect of consumption of virgin coconut oil (VCO) on various lipid parameters in comparison with copra oil (CO). In addition, the preventive effect of polyphenol fraction (PF) from test oils on copper induced oxidation of LDL and carbonyl formation was also studied. Design and methods: After 45 days of oil feeding to Sprague–Dawley rats, several lipid parameters and lipoprotein levels were determined. PF was isolated from the oils an...
199 CitationsSource
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