A novel rapamycin analog is highly selective for mTORC1 in vivo
Abstract
Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment of age-related diseases. However, rapamycin exerts metabolic and immunological side effects mediated by off-target inhibition of a second mTOR-containing complex, mTOR complex 2. Here, we report the identification of DL001, a FKBP12-dependent rapamycin analog 40x more selective for mTORC1 than rapamycin....
Paper Details
Title
A novel rapamycin analog is highly selective for mTORC1 in vivo
Published Date
Jul 19, 2019
Journal
Volume
10
Issue
1
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