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A Manifold Regularized Multi-Task Learning Model for IQ Prediction from Two fMRI Paradigms

Published on Jan 1, 2019in IEEE Transactions on Biomedical Engineering4.491
· DOI :10.1109/TBME.2019.2921207
Li Xiao1
Estimated H-index: 1
(Tulane University),
Julia M. Stephen22
Estimated H-index: 22
(The Mind Research Network)
+ 2 AuthorsYu-Ping Wang22
Estimated H-index: 22
(Tulane University)
Abstract
Objective: Multi-modal brain functional connectivity (FC) data have shown great potential for providing insights into individual variations in behavioral and cognitive traits. The joint learning of multi-modal data can utilize the intrinsic association, and thus can boost the learning performance. Although several multi-task based learning models have already been proposed by viewing the feature learning on each modality as one task, most of them ignore the structural information inherent across the modalities, which may play an important role in extracting discriminative features. Methods: In this paper, we propose a new manifold regularized multi-task learning model by simultaneously considering between-subject and between-modality relationships. Specifically, the l_{2,1} -norm (i.e., group-sparsity) regularizer is enforced to jointly select a few common features across different modalities. A novelly designed manifold regularizer is further imposed as a crucial underpinning to preserve the structural information both within and between modalities. Such designed regularizers will make our model more adaptive to realistic neuroimaging data, which are usually of small sample size but high dimensional features. Results: Our model is then validated on the Philadelphia Neurodevelopmental Cohort dataset, where we regard our modalities as functional MRI (fMRI) data collected under two paradigms. Specifically, we conduct experimental studies on fMRI based FC network data in two task conditions for intelligence quotient (IQ) prediction. The results demonstrate that our proposed model can not only achieve improved prediction performance, but also yield a set of IQ-relevant biomarkers. Conclusion and Significance: This paper develops a new multi-task learning model, enabling the discovery of significant biomarkers which may account for a proportion of the variance in human intelligence.
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