Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Abstract
Group II introns are a class of retroelements that invade DNA through a copy-and-paste mechanism known as retrotransposition. Their coordinated activities occur within a complex that includes a maturase protein, which promotes splicing through an unknown mechanism. The mechanism of splice site exchange within the RNA active site during catalysis also remains unclear. We determined two cryo-EM structures at 3.6-A resolution of a group II intron...
Paper Details
Title
Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Published Date
Jul 25, 2019
Journal
Volume
178
Issue
3
Pages
612
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