Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD
Abstract
Methods to create genetically engineered mice involve three major steps: harvesting embryos from one set of females, microinjection of reagents into embryos ex vivo and their surgical transfer to another set of females. Although tedious, these methods have been used for more than three decades to create mouse models. We recently developed a method named GONAD (genome editing via oviductal nucleic acids delivery), which bypasses these steps....
Paper Details
Title
Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD
Published Date
Jul 24, 2019
Journal
Volume
14
Issue
8
Pages
2452 - 2482
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