Determining the water solubility of difficult-to-test substances: A tutorial review

Water solubility is one of the most important and frequently used physical-chemical properties of chemicals. It is crucial within several industrial sectors, in research and in the regulatory sector e.g. for the risk and hazard assessment of chemicals. The most recent OECD guideline (Test No. 105) for measuring solubility is from 1995 and limited to mono-constituent, stable and non-volatile substances. This OECD guideline and the described...