A nonparametric Bayesian basket trial design
Abstract
Targeted therapies on the basis of genomic aberrations analysis of the tumor have shown promising results in cancer prognosis and treatment. Regardless of tumor type, trials that match patients to targeted therapies for their particular genomic aberrations have become a mainstream direction of therapeutic management of patients with cancer. Therefore, finding the subpopulation of patients who can most benefit from an aberration-specific targeted...
Paper Details
Title
A nonparametric Bayesian basket trial design
Published Date
May 28, 2018
Journal
Volume
61
Issue
5
Pages
1160 - 1174
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