Synergistic Effect of NELL-1 and an Ultra-Low Dose of BMP-2 on Spinal Fusion
Abstract
Bone morphogenetic protein 2 (BMP-2) is widely used in spinal fusion but it can cause adverse effects such as ectopic bone and adipose tissue in vivo. Neural epidermal growth factor like-like molecule-1 (NELL-1) has been shown to suppress BMP-2-induced adverse effects. However, no optimum carriers that control both NELL-1 and BMP-2 releases to elicit long-term bioactivity have been developed. In this study, we employed polyelectrolyte complex...
Paper Details
Title
Synergistic Effect of NELL-1 and an Ultra-Low Dose of BMP-2 on Spinal Fusion
Published Date
Dec 1, 2019
Journal
Volume
25
Issue
23-24
Pages
1677 - 1689
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