Modular and tunable biological feedback control using a de novo protein switch
Abstract
De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein of interest in vivo upon induction by a genetically encoded small peptide. Here we leverage the plug-and-play nature of degronLOCKR...
Paper Details
Title
Modular and tunable biological feedback control using a de novo protein switch
Published Date
Jul 24, 2019
Journal
Volume
572
Issue
7768
Pages
265 - 269
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