Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer
Abstract
Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative phosphorylation (OXPHOS) to fuel its growth, however, broadly inhibiting this pathway might also disrupt essential mitochondrial functions in normal tissues. PDAC cells exhibit abnormally fragmented mitochondria that are essential to its oncogenicity, but it was unclear if this mitochondrial feature was a valid therapeutic target. Here, we present evidence that normalizing...
Paper Details
Title
Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer
Published Date
Aug 22, 2019
Journal
Volume
4
Issue
16
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