Boosting NAD+ with a small molecule that activates NAMPT.
Abstract
Pharmacological strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of nicotinamide mononucleotide (NMN), the predominant NAD+ precursor in mammalian cells. A high-throughput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is structurally similar to active-site...
Paper Details
Title
Boosting NAD+ with a small molecule that activates NAMPT.
Published Date
Jul 19, 2019
Journal
Volume
10
Issue
1
Pages
3241
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