Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration
Abstract
The epicardium and its derivatives provide trophic and structural support for the developing and adult heart. Here we tested the ability of human embryonic stem cell (hESC)-derived epicardium to augment the structure and function of engineered heart tissue in vitro and to improve efficacy of hESC-cardiomyocyte grafts in infarcted athymic rat hearts. Epicardial cells markedly enhanced the contractility, myofibril structure and calcium handling of...
Paper Details
Title
Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration
Published Date
Aug 1, 2019
Journal
Volume
37
Issue
8
Pages
895 - 906
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