ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
Abstract
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3...
Paper Details
Title
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
Published Date
Jul 19, 2019
Journal
Volume
10
Issue
1
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