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Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles

Published on Aug 1, 2019in Physica Medica2.532
· DOI :10.1016/j.ejmp.2019.06.001
A. Rucinski8
Estimated H-index: 8
,
G. Traini7
Estimated H-index: 7
+ 17 AuthorsV. Patera31
Estimated H-index: 31
Abstract
Abstract Particle therapy is a therapy technique that exploits protons or light ions to irradiate tumor targets with high accuracy. Protons and 12 C ions are already used for irradiation in clinical routine, while new ions like 4 He and 16 O are currently being considered. Despite the indisputable physical and biological advantages of such ion beams, the planning of charged particle therapy treatments is challenged by range uncertainties, i.e. the uncertainty on the position of the maximal dose release (Bragg Peak – BP), during the treatment. To ensure correct ‘in-treatment’ dose deposition, range monitoring techniques, currently missing in light ion treatment techniques, are eagerly needed. The results presented in this manuscript indicate that charged secondary particles, mainly protons, produced by an 16 O beam during target irradiation can be considered as candidates for 16 O beam range monitoring. Hereafter, we report on the first yield measurements of protons, deuterons and tritons produced in the interaction of an 16 O beam impinging on a PMMA target, as a function of detected energy and particle production position. Charged particles were detected at 90° and 60° with respect to incoming beam direction, and homogeneous and heterogeneous PMMA targets were used to probe the sensitivity of the technique to target inhomogeneities. The reported secondary particle yields provide essential information needed to assess the accuracy and resolution achievable in clinical conditions by range monitoring techniques based on secondary charged radiation.
  • References (34)
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References34
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#1A. Rucinski (PAN: Polish Academy of Sciences)H-Index: 8
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#1J. Krimmer (University of Lyon)H-Index: 12
#2Denis Dauvergne (CNRS: Centre national de la recherche scientifique)H-Index: 19
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Abstract Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have be...
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#1Yunhe Xie (UPenn: University of Pennsylvania)H-Index: 2
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In light ion beam therapy, positron (β+) emitters are produced by the tissue nuclei through nuclear interactions with the beam ions. They can be used for the verification of the delivered dose using positron emission tomography by comparing the spatial distribution of the β+ emitters activity to a computer simulation taking into account the patient morphology and the treatment plan. However, the accuracy of the simulation greatly depends on the method used to generate the nuclear interactions pr...
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Nowadays there is a growing interest in particle therapy treatments exploiting light ion beams against tumors due to their enhanced relative biological effectiveness and high space selectivity. In particular promising results are obtained by the use of 4He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Io...
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