Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles

Published on Aug 1, 2019in Physica Medica2.532
· DOI :10.1016/j.ejmp.2019.06.001
A. Rucinski8
Estimated H-index: 8
G. Traini7
Estimated H-index: 7
+ 17 AuthorsV. Patera31
Estimated H-index: 31
Abstract Particle therapy is a therapy technique that exploits protons or light ions to irradiate tumor targets with high accuracy. Protons and 12 C ions are already used for irradiation in clinical routine, while new ions like 4 He and 16 O are currently being considered. Despite the indisputable physical and biological advantages of such ion beams, the planning of charged particle therapy treatments is challenged by range uncertainties, i.e. the uncertainty on the position of the maximal dose release (Bragg Peak – BP), during the treatment. To ensure correct ‘in-treatment’ dose deposition, range monitoring techniques, currently missing in light ion treatment techniques, are eagerly needed. The results presented in this manuscript indicate that charged secondary particles, mainly protons, produced by an 16 O beam during target irradiation can be considered as candidates for 16 O beam range monitoring. Hereafter, we report on the first yield measurements of protons, deuterons and tritons produced in the interaction of an 16 O beam impinging on a PMMA target, as a function of detected energy and particle production position. Charged particles were detected at 90° and 60° with respect to incoming beam direction, and homogeneous and heterogeneous PMMA targets were used to probe the sensitivity of the technique to target inhomogeneities. The reported secondary particle yields provide essential information needed to assess the accuracy and resolution achievable in clinical conditions by range monitoring techniques based on secondary charged radiation.
  • References (34)
  • Citations (0)
📖 Papers frequently viewed together
4 Authors (Uwe Titt, ..., Radhe Mohan)
1 Citations
17 Authors (R. Mirabelli, ..., V. Patera)
78% of Scinapse members use related papers. After signing in, all features are FREE.
In vivo range monitoring techniques are necessary in order to fully take advantage of the high dose gradients deliverable in hadrontherapy treatments. Positron emission tomography (PET) scanners can be used to monitor beam-induced activation in tissues and hence measure the range. The INSIDE (Innovative Solutions for In-beam DosimEtry in Hadrontherapy) in-beam PET scanner, installed at the Italian National Center of Oncological Hadrontherapy (CNAO, Pavia, Italy) synchrotron facility, has already...
4 CitationsSource
#1A. Rucinski (PAN: Polish Academy of Sciences)H-Index: 8
#2G. BattistoniH-Index: 48
Last. V. PateraH-Index: 31
view all 21 authors...
4 CitationsSource
#1J. Krimmer (University of Lyon)H-Index: 12
#2Denis Dauvergne (CNRS: Centre national de la recherche scientifique)H-Index: 19
Last. Etienne Testa (University of Lyon)H-Index: 18
view all 4 authors...
Abstract Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have be...
40 CitationsSource
#1O. SokolH-Index: 2
#2Emanuele ScifoniH-Index: 11
Last. Michael S. KramerH-Index: 95
view all 11 authors...
Nowadays there is a rising interest towards exploiting new therapeutical beams beyond carbon ions and protons. In particular, 16O ions are being widely discussed due to their increased LET distribution. In this contribution, we report on the first experimental verification of biologically optimized treatment plans, accounting for different biological effects, generated with the TRiP98 planning system with 16O beams, performed at HIT and GSI. This implies the measurements of 3D profiles of absorb...
9 CitationsSource
#1Yunhe Xie (UPenn: University of Pennsylvania)H-Index: 2
Last. Boon-Keng Kevin Teo (UPenn: University of Pennsylvania)H-Index: 17
view all 16 authors...
Purpose To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil bea...
35 CitationsSource
#1Marco Durante (University of Naples Federico II)H-Index: 44
#2Roberto OrecchiaH-Index: 6
Last. Jay S. Loeffler (Harvard University)H-Index: 88
view all 3 authors...
Conventional radiotherapy with X-rays is being replaced by radiotherapy with high-energy charged particles, an approach that better spares healthy tissue from radiation but is associated with higher costs. Evidence supporting the cost-effectiveness of either modality can only come from the results of randomized clinical trials. The authors of this Review discuss ongoing randomized trials of charged-particle therapies as well as aspects related to radiobiology, which need to be taken into account...
81 CitationsSource
#1Anna Merle Reinhart (DKFZ: German Cancer Research Center)H-Index: 2
#2C.K. Spindeldreier (DKFZ: German Cancer Research Center)H-Index: 3
Last. Maria Martisikova (DKFZ: German Cancer Research Center)H-Index: 4
view all 4 authors...
Carbon ion beam radiotherapy enables a very localised dose deposition. However, even small changes in the patient geometry or positioning errors can significantly distort the dose distribution. A live, non-invasive monitoring system of the beam delivery within the patient is therefore highly desirable, and could improve patient treatment. We present a novel three-dimensional method for imaging the beam in the irradiated object, exploiting the measured tracks of single secondary ions emerging und...
9 CitationsSource
#1T. Gaa (DKFZ: German Cancer Research Center)H-Index: 1
#2M. Reinhart (DKFZ: German Cancer Research Center)H-Index: 1
Last. Maria Martisikova (DKFZ: German Cancer Research Center)H-Index: 4
view all 7 authors...
Abstract Purpose Non-invasive methods for monitoring of the therapeutic ion beam extension in the patient are desired in order to handle deteriorations of the dose distribution related to changes of the patient geometry. In carbon ion radiotherapy, secondary light ions represent one of potential sources of information about the dose distribution in the irradiated target. The capability to detect range-changing inhomogeneities inside of an otherwise homogeneous phantom, based on single track meas...
3 CitationsSource
#1S. SalvadorH-Index: 3
Last. M. LabalmeH-Index: 9
view all 6 authors...
In light ion beam therapy, positron (β+) emitters are produced by the tissue nuclei through nuclear interactions with the beam ions. They can be used for the verification of the delivered dose using positron emission tomography by comparing the spatial distribution of the β+ emitters activity to a computer simulation taking into account the patient morphology and the treatment plan. However, the accuracy of the simulation greatly depends on the method used to generate the nuclear interactions pr...
3 CitationsSource
#1M. MarafiniH-Index: 10
#2R. ParamattiH-Index: 23
Last. V. PateraH-Index: 31
view all 22 authors...
Nowadays there is a growing interest in particle therapy treatments exploiting light ion beams against tumors due to their enhanced relative biological effectiveness and high space selectivity. In particular promising results are obtained by the use of 4He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Io...
9 CitationsSource
Cited By0