Complex Transmission Patterns and Age-Related Dynamics of a Selfish mtDNA Deletion

Volume: 59, Issue: 4, Pages: 983 - 993
Published: Jul 18, 2019
Abstract
Despite wide-ranging implications of selfish mitochondrial DNA (mtDNA) elements for human disease and topics in evolutionary biology (e.g., speciation), the forces controlling their formation, age-related accumulation, and offspring transmission remain largely unknown. Selfish mtDNA poses a significant challenge to genome integrity, mitochondrial function, and organismal fitness. For instance, numerous human diseases are associated with mtDNA...
Paper Details
Title
Complex Transmission Patterns and Age-Related Dynamics of a Selfish mtDNA Deletion
Published Date
Jul 18, 2019
Volume
59
Issue
4
Pages
983 - 993
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