Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire
Abstract
The loci encoding B and T cell Ag receptors are generally distinct in commonly studied mammals, with each receptor’s gene segments limited to intralocus, cis chromosomal rearrangements. The nurse shark (Ginglymostoma cirratum) represents the oldest vertebrate class, the cartilaginous fish, with adaptive immunity provided via Ig and TCR lineages, and is one species among a growing number of taxa employing Ig-TCRδ rearrangements that blend these...
Paper Details
Title
Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire
Published Date
Sep 1, 2019
Journal
Volume
203
Issue
5
Pages
1265 - 1275
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