Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia

Abstract
Apolipoprotein E ( APOE ) ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD). Although its association with AD is well-established, the impact of APOE ε4 on human brain cell function remains unclear. Here we investigated the effects of APOE ε4 on several brain cell types derived from human induced pluripotent stem cells and human APOE targeted replacement mice. Gene set enrichment and pathway analyses of whole transcriptome...
Paper Details
Title
Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia
DOI
Published Date
Jul 25, 2019
Journal
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