Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Abstract
HCN channels underlie the depolarizing funny current (I f ) that contributes importantly to cardiac pacemaking. I f is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic mice ( HCN4 tg/wt ) to assess functional consequences of HCN4 overexpression-mediated I f increase in cardiomyocytes to levels observed in human heart failure. HCN4 tg/wt animals exhibit a dilated...
Paper Details
Title
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Published Date
Jul 23, 2019
Journal
Volume
10
Issue
1
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