Osmotically Inactivated Sodium in Acute Hyponatremia: Stay With Edelman

Related Article, p. 320 Related Article, p. 320 Plasma sodium concentration ([Na+]) generally accurately reflects plasma tonicity because sodium and its anions account for almost all the effective osmoles in the extracellular fluid (ECF). Given that the hydraulic permeability of most cell membranes is very high, water transits quickly and freely between the ECF and the intracellular fluid, resulting in equal tonicity in both. In the...