Coordination driven self-assembly for enhancing the biological stability of nobiletin

In our previous study, zein nanoparticles (NPs) coupled with tannic acid (TA) and metal ions coatings have been successfully introduced in delivery systems as effective carriers for anticancer drug delivery. Herein, nobiletin (NOB), a kind of low soluble and crystallizable nutraceutical, was encapsulated into these NPs engineered from zein, TA and different metal ions (named ZT-metal NPs) to achieve high loading capacity (LC) and long-term...