Original paper
A system for site-specific integration of transgenes in mammalian cells
Abstract
Mammalian cell expression systems are the most commonly used platforms for producing biotherapeutic proteins. However, development of recombinant mammalian cell lines is often hindered by the unstable and variable transgene expression associated with random integration. We have developed an efficient strategy for site-specific integration of genes of interest (GOIs). This method enables rapid and precise insertion of a gene expression cassette...
Paper Details
Title
A system for site-specific integration of transgenes in mammalian cells
Published Date
Jul 25, 2019
Journal
Volume
14
Issue
7
Pages
e0219842 - e0219842
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Notes
History