PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases
Volume: 4, Issue: 16
Published: Aug 22, 2019
Abstract
Chronic inflammation causes target organ damage in patients with systemic autoimmune diseases. The factors that allow this protracted response are poorly understood. We analyzed the transcriptional regulation of PPP2R2B (B55β), a molecule necessary for the termination of the immune response, in patients with autoimmune diseases. Altered expression of B55β conditioned resistance to cytokine withdrawal–induced death (CWID) in patients with...
Paper Details
Title
PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases
Published Date
Aug 22, 2019
Volume
4
Issue
16
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