Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells

Background & AimsMethyl-CpG binding protein 2, MECP2, which binds to methylated regions of DNA to regulate transcription, is expressed by hepatic stellate cells (HSCs) and is required for development of liver fibrosis in mice. We investigated the effects of MECP2 deletion from HSCs on their transcriptome and of phosphorylation of MECP2 on HSC phenotype and liver fibrosis.MethodsWe isolated HSCs from Mecp2–/y mice and wild-type (control) mice....