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Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Published on Dec 1, 2019in BMC Cancer 2.93
· DOI :10.1186/s12885-019-5901-0
Weiwei Gong (TUM: Technische Universität München), Yueyang Liu1
Estimated H-index: 1
(TUM: Technische Universität München)
+ 6 AuthorsJulia Dorn14
Estimated H-index: 14
(TUM: Technische Universität München)
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Abstract
Background In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In this study, we have analyzed the KLK5 mRNA expression pattern in tumor tissue of patients suffering from high-grade serous ovarian cancer stage FIGO III/IV. Moreover, we have correlated the KLK5 mRNA levels with clinical outcome.
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Published on Oct 1, 2018in British Journal of Cancer 5.42
Ping Wang1
Estimated H-index: 1
(TUM: Technische Universität München),
Viktor Magdolen38
Estimated H-index: 38
(TUM: Technische Universität München)
+ 9 AuthorsAnja Rockstroh5
Estimated H-index: 5
(QUT: Queensland University of Technology)
Tissue kallikrein-related peptidases 4, 5, 6 and 7 (KLK4–7) strongly increase the malignancy of ovarian cancer cells. Deciphering their downstream effectors, we aimed at finding new potential prognostic biomarkers and treatment targets for ovarian cancer patients. KLK4–7-transfected (OV-KLK4–7) and vector-control OV-MZ-6 (OV-VC) ovarian cancer cells were established to select differentially regulated factors. With three independent approaches, PCR arrays, genome-wide microarray and proteome anal...
Published on Apr 1, 2016in American Journal of Pathology 3.76
Robert J. Kurman107
Estimated H-index: 107
(Johns Hopkins University),
IeM Shih76
Estimated H-index: 76
(Johns Hopkins University)
Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a decade ago, a large number of molecular and histopathologic studies were published that have provided important insights into the origin and molecular pathogenesis of this disease. This has required that the original model be revised and expanded to incorporate these findings. The new model divides type I tumors into three groups: i) endometriosis-related tumors that include endometrioid, clear cell, and ser...
Published on Jan 1, 2016in Biological Chemistry 3.01
Nancy Ahmed2
Estimated H-index: 2
(TUM: Technische Universität München),
Julia Dorn14
Estimated H-index: 14
(TUM: Technische Universität München)
+ 9 AuthorsEleftherios P. Diamandis97
Estimated H-index: 97
(U of T: University of Toronto)
Most members of the kallikrein-related peptidase family have been demonstrated to be dysregulated in ovarian cancer and modulate tumor growth, migration, invasion, and resistance to chemotherapy. In the present study, we assessed the mRNA expression levels of KLK6 and KLK8 by quantitative PCR in 100 patients with advanced serous ovarian cancer FIGO stage III/IV. A pronounced correlation between KLK6 and KLK8 mRNA expression (rs = 0.636, p< 0.001) was observed, indicating coordinate expression of...
Published on May 1, 2015in Nature 43.07
Ann-Marie Patch24
Estimated H-index: 24
(UQ: University of Queensland),
Elizabeth L. Christie7
Estimated H-index: 7
(Peter MacCallum Cancer Centre)
+ 79 AuthorsPeter J. Bailey31
Estimated H-index: 31
(Glas.: University of Glasgow)
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-genome sequencing of tumour and germline DNA samples from 92 patients with primary refractory, resistant, sensitive and matched acquired resistant disease. We show that gene breakage commonly inactiva...
Published on Mar 1, 2015in Nature Reviews Drug Discovery 57.62
Ioannis Prassas13
Estimated H-index: 13
,
Azza Eissa5
Estimated H-index: 5
+ 1 AuthorsEleftherios P. Diamandis97
Estimated H-index: 97
Members of the family of kallikrein (KLK)-related proteases are found in various tissues — including the airway, prostate and brain — and have a wide range of functions. The authors describe the roles of KLKs in health and disease, and highlight the small-molecule, peptide-based, protein-based, antibody-based and immunotherapeutic strategies that are being used to target KLKs in certain diseases.
Published on Jan 23, 2015in Science 41.04
Mathias Uhlén90
Estimated H-index: 90
(KTH: Royal Institute of Technology),
Linn Fagerberg21
Estimated H-index: 21
(KTH: Royal Institute of Technology)
+ 33 AuthorsAnna Asplund28
Estimated H-index: 28
(Science for Life Laboratory)
Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map ...
Published on Jan 1, 2015in Oncology Letters 1.87
Julia Dorn14
Estimated H-index: 14
(TUM: Technische Universität München),
Holger Bronger10
Estimated H-index: 10
(TUM: Technische Universität München)
+ 7 AuthorsNadia Harbeck73
Estimated H-index: 73
(LMU: Ludwig Maximilian University of Munich)
Following primary debulking surgery, the presence of a residual tumor mass is one of the most important prognostic factors in ovarian cancer. In a previous study, we established the OVSCORE, an algorithm to predict surgical outcome, based on the clinical factors of nuclear grading and ascitic fluid volume, plus the cancer biomarkers, kallikrein-related peptidases (KLKs), KLK6 and KLK13. In the present study, OVSCORE performance was tested in an independent ovarian cancer patient cohort consistin...
Published on Oct 24, 2014
Konstantinos Gus Sidiropoulos8
Estimated H-index: 8
,
Nicole M.A. White21
Estimated H-index: 21
+ 7 AuthorsGeorge M. Yousef57
Estimated H-index: 57
(St. Michael's Hospital)
Kallikrein-related peptidase 5 (KLK5) displays aberrant expression in cancer. Recently, we showed KLK5 reconstitution in breast cancer cell lines suppresses malignancy. Present study aims to investigate the functional KLK5 mediated miRNA network on breast cancer progression, molecular subtype and survival. 28 miRNAs were up-regulated and 62 miRNAs were down-regulated upon KLK5 expression. Extracellular matrix (ECM) molecules and cell-adhesion pathways were the most significant KLK5-induced miRNA...
Published on Apr 1, 2014in Critical Reviews in Clinical Laboratory Sciences 4.82
Julia Dorn14
Estimated H-index: 14
(LMU: Ludwig Maximilian University of Munich),
Nathalie Beaufort13
Estimated H-index: 13
(LMU: Ludwig Maximilian University of Munich)
+ 3 AuthorsViktor Magdolen38
Estimated H-index: 38
(LMU: Ludwig Maximilian University of Munich)
AbstractGynecological cancers, including malignant tumors of the ovaries, the endometrium and the cervix, account for approximately 10% of tumor-associated deaths in women of the Western world. For screening, diagnosis, prognosis, and therapy response prediction, the group of enzymes known as serine (Ser-)proteases show great promise as biomarkers. In the present review, following a summary of the clinical facts regarding malignant tumors of the ovaries, the endometrium and the cervix, and chara...
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