A gene regulatory network explains RET–EDNRB epistasis in Hirschsprung disease
Abstract
Disruptions in gene regulatory networks (GRNs), driven by multiple deleterious variants, potentially underlie complex traits and diseases. Hirschsprung disease (HSCR), a multifactorial disorder of enteric nervous system (ENS) development, is associated with at least 24 genes and seven chromosomal loci, with RET and EDNRB as its major genes. We previously demonstrated that RET transcription in the ENS is controlled by an extensive GRN involving...
Paper Details
Title
A gene regulatory network explains RET–EDNRB epistasis in Hirschsprung disease
Published Date
Sep 15, 2019
Journal
Volume
28
Issue
18
Pages
3137 - 3147
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