Filamin A mediates isotropic distribution of applied force across the actin network
Abstract
Cell sensing of externally applied mechanical strain through integrin-mediated adhesions is critical in development and physiology of muscle, lung, tendon, and arteries, among others. We examined the effects of strain on force transmission through the essential cytoskeletal linker talin. Using a fluorescence-based talin tension sensor (TS), we found that uniaxial stretch of cells on elastic substrates increased tension on talin, which was...
Paper Details
Title
Filamin A mediates isotropic distribution of applied force across the actin network
Published Date
Jul 17, 2019
Journal
Volume
218
Issue
8
Pages
2481 - 2491
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