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Clonality testing as complementary tool in the assessment of different patient groups with canine chronic enteropathy

Published on Jul 1, 2019in Veterinary Immunology and Immunopathology1.85
· DOI :10.1016/j.vetimm.2019.109893
N. Luckschander-Zeller2
Estimated H-index: 2
(University of Veterinary Medicine Vienna),
Sabine E. Hammer14
Estimated H-index: 14
(University of Veterinary Medicine Vienna)
+ 6 AuthorsIwan A. Burgener (University of Veterinary Medicine Vienna)
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Abstract
Abstract Differentiation between canine chronic enteropathy (CCE) and intestinal lymphoma is a diagnostic challenge as histopathology might fail to yield unequivocal results. Detection of clonal rearrangements of the T-cell-receptor gamma (TCRG) chain and IG heavy chain (IGH) V-J genes offer a useful solution. In this retrospective study, histopathology samples of 35 CCE patients and 7 healthy Beagle dogs underwent clonality testing. Patients suffered either from inflammatory bowel disease (IBD), food responsive diarrhea (FRD) or protein loosing enteropathy secondary to IBD (PLE/IBD). Healthy Beagles served as controls (CO). Canine IBD activity index (CIBDAI) and histopathological WSAVA–grading differed significantly (p 0.001) between groups. CIBDAI improved significantly after appropriate therapy (p
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Published on Sep 1, 2018in Veterinary and Comparative Oncology2.38
K. M. Couto (AmeriCorps VISTA), Peter F. Moore47
Estimated H-index: 47
(UC Davis: University of California, Davis)
+ 2 AuthorsKatherine A Skorupski13
Estimated H-index: 13
(UC Davis: University of California, Davis)
Published on Aug 1, 2018in Current Hematologic Malignancy Reports2.40
Udit Chander1
Estimated H-index: 1
(CUMC: Columbia University Medical Center),
Rebecca Leeman-Neill2
Estimated H-index: 2
(CUMC: Columbia University Medical Center),
Govind Bhagat53
Estimated H-index: 53
(CUMC: Columbia University Medical Center)
Purpose of Review To provide an update on the pathogenesis of enteropathy-associated T cell lymphoma (EATL) and its relationship with refractory celiac disease (RCD), in light of current knowledge of immune, genetic, and environmental factors that promote neoplastic transformation of intraepithelial lymphocytes (IELs).
Published on Mar 1, 2018in Journal of Small Animal Practice1.25
J. Lane1
Estimated H-index: 1
(UT: University of Tennessee),
J. Price1
Estimated H-index: 1
(UT: University of Tennessee)
+ 5 AuthorsClaire M. Cannon3
Estimated H-index: 3
(UMN: University of Minnesota)
Objectives To report the clinical presentation, treatment and prognosis of dogs with low-grade gastrointestinal lymphoma. Materials and Methods Cases were solicited from the American College of Veterinary Internal Medicine Oncology Diplomate listserv. Medical records of dogs with low-grade gastrointestinal lymphoma diagnosed via a combination of histology and immunohistochemistry with or without analysis of polymerase chain reaction for antigen receptor rearrangement were included. Signalment, c...
Published on Dec 1, 2017in Veterinary and Comparative Oncology2.38
Sabine E. Hammer14
Estimated H-index: 14
(University of Veterinary Medicine Vienna),
Sandra Groiss4
Estimated H-index: 4
(University of Veterinary Medicine Vienna)
+ 6 AuthorsBarbara C. Rütgen7
Estimated H-index: 7
(University of Veterinary Medicine Vienna)
Differentiation between resident mature lymphocyte populations and small cell lymphoma cannot be made by cytological review alone and remains challenging in histopathological review. These cases warrant application of complementary tools like PCR-based immunoglobulin (IG) and T-cell receptor (TCR) clonality testing for confirmation. In this prospective study, diagnostic sensitivity and specificity of different primer sets for routine diagnosis of feline TCR gamma (TCRG) and complete IG heavy cha...
Published on Jan 1, 2017in Journal of Veterinary Medical Science0.91
Aki Ohmi7
Estimated H-index: 7
(UTokyo: University of Tokyo),
Koichi Ohno36
Estimated H-index: 36
(UTokyo: University of Tokyo)
+ 5 AuthorsHajime Tsujimoto23
Estimated H-index: 23
(UTokyo: University of Tokyo)
Published on Aug 1, 2016in Research in Veterinary Science1.75
Verena Gress1
Estimated H-index: 1
(University of Veterinary Medicine Vienna),
Birgitt Wolfesberger10
Estimated H-index: 10
(University of Veterinary Medicine Vienna)
+ 5 AuthorsSabine E. Hammer14
Estimated H-index: 14
(University of Veterinary Medicine Vienna)
Abstract Feline alimentary lymphoma is the most common hematopoietic neoplasia in cats. It affects mainly the small intestines and is most frequently of T-cell origin. Evaluation of a fine needle aspirate is often the first step in the diagnostic work-up. Differentiation between a resident mature lymphocyte population as encountered in inflammatory bowel disease and small cell lymphoma cannot be achieved by cytology alone. Even full thickness biopsies evaluated by histopathology can be inconclus...
Published on Jul 1, 2016in Veterinary Pathology2.12
Stefan M. Keller11
Estimated H-index: 11
(Ontario Veterinary College),
William Vernau23
Estimated H-index: 23
(UC Davis: University of California, Davis),
Peter F. Moore47
Estimated H-index: 47
(UC Davis: University of California, Davis)
The accurate distinction of reactive and neoplastic lymphoid proliferations can present challenges. Given the different prognoses and treatment strategies, a correct diagnosis is crucial. Molecular clonality assays assess rearranged lymphocyte antigen receptor gene diversity and can help differentiate reactive from neoplastic lymphoid proliferations. Molecular clonality assays are commonly used to assess atypical, mixed, or mature lymphoid proliferations; small tissue fragments that lack archite...
Published on Mar 1, 2016in Veterinary Clinical Pathology0.95
Barbara C. Rütgen7
Estimated H-index: 7
(University of Veterinary Medicine Vienna),
Irene Flickinger2
Estimated H-index: 2
(University of Veterinary Medicine Vienna)
+ 5 AuthorsIlse Schwendenwein16
Estimated H-index: 16
(University of Veterinary Medicine Vienna)
A 7-year-old male Boxer with a 3.5-year history of atopy and food hypersensitivity was presented with multiple poorly circumscribed nodules and maculae of the skin and tongue, and jaundiced mucosal membranes. Cytologic and histopathologic examination of the skin lesions revealed cutaneous epitheliotropic lymphoma. Cells were CD3+ and CD8+ in flow cytometry. The CBC showed a moderate leukocytosis with 16% atypical lymphocytes with irregularly cleaved nuclei. Flow cytometric phenotyping of periphe...
Published on Jul 1, 2015in Veterinary Journal1.92
Ko Nakashima13
Estimated H-index: 13
(UTokyo: University of Tokyo),
Saaya Hiyoshi3
Estimated H-index: 3
(UTokyo: University of Tokyo)
+ 6 AuthorsHajime Tsujimoto23
Estimated H-index: 23
(UTokyo: University of Tokyo)
Abstract Canine protein-losing enteropathy (PLE) is associated with severe gastrointestinal disorders and has a guarded to poor prognosis although little information is available regarding factors affecting prognosis. The purpose of this study was to identify the prognostic factors for survival of dogs with PLE. Ninety-two dogs diagnosed with PLE from 2006 to 2011 were included in a retrospective cohort study. Survival analysis was performed using the Kaplan–Meier method and log-rank test. Varia...
Published on Jul 1, 2015in Veterinary Pathology2.12
V. Carrasco2
Estimated H-index: 2
(Veterinary Medical Teaching Hospital),
A. Rodriguez-Bertos4
Estimated H-index: 4
(Complutense University of Madrid)
+ 4 AuthorsMatti Kiupel38
Estimated H-index: 38
Inflammatory bowel disease (IBD) and intestinal lymphoma are intestinal disorders in dogs, both causing similar chronic digestive signs, although with a different prognosis and different treatment requirements. Differentiation between these 2 conditions is based on histopathologic evaluation of intestinal biopsies. However, an accurate diagnosis is often difficult based on histology alone, especially when only endoscopic biopsies are available to differentiate IBD from enteropathy-associated T-c...
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