Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
Abstract
Self-amplifying RNA (saRNA) is a promising biotherapeutic tool that has been used as a vaccine against both infectious diseases and cancer. saRNA has been shown to induce protein expression for up to 60 days and elicit immune responses with lower dosing than messenger RNA (mRNA). Because saRNA is a large (~9500 nt), negatively charged molecule, it requires a delivery vehicle for efficient cellular uptake and degradation protection. Lipid...
Paper Details
Title
Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
Published Date
Jul 12, 2019
Journal
Volume
26
Issue
9
Pages
363 - 372
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